A new perspective on vitamin A for premature infants

In a 1999 landmark trial, Tyson et al (N Engl J Med 1999;340:1962-8. https://doi.org/10.1056/NEJM199906243402505) reported that 4 weeks of intramuscular vitamin A reduced deficiency and modestly bronchopulmonary dysplasia (BPD) or death in preterm infants <1000 grams (relative risk, 0.89). However, clinical practice, the use remains variable, large part because concerns about pain injections along with modest benefit. It is only natural to consider selective for at highest risk poor outcomes, such as those who require higher levels oxygen mechanical ventilation support. this volume The Journal, Rysavy report just opposite. When data from original trial were analyzed based on BPD individual patient level, therapy had greatest benefit lowest death. These fit well into growing appreciation all extremely babies are abnormal lung function during their life span: Even appear relatively healthy initial hospitalization substantial long-term respiratory morbidity (J Pediatr 2021;234:257-9. https://doi.org/10.1016/j.jpeds.2021.03.063). time revisit low-risk option optimize alveolarization development subset babies. Article page 78 ▸ Should Vitamin Injections Prevent Bronchopulmonary Dysplasia Death Be Reserved High-Risk Infants? Reanalysis National Institute Child Health Human Development Neonatal Research Network Randomized TrialThe Journal PediatricsVol. 236PreviewTo determine whether more than lower risk. Full-Text PDF